Fundamentals and Biotherapeutics Applications of Multi-Angle and Dynamic Light Scattering
Presented by: Udayabagya "Bud" Halim, Ph.D., Waters | Wyatt Technology
Presented Live: August 28th, 2024
Biophysical techniques such as multi-angle light scattering (MALS) and dynamic light scattering (DLS) address numerous critical analytical challenges in biotherapeutic formulation development, including the screening for aggregation, colloidal and conformational stability, viscosity, and chemical modifications.
In this webinar, we will delve into the fundamentals and advantages of SEC-MALS and DLS for the biophysical characterization of monoclonal antibodies (mAbs), conjugated proteins, and adeno-associated viruses (AAVs). We will present key analytical methods utilizing the latest MALS, DLS, and refractive index (RI) instrumentation to obtain absolute molecular weight, size, and composition of biotherapeutics.