Unveiling CQA Insights for mRNA, LNPs and Viral Vectors by SEC and MALS with Novel 1000 Å Ultrawide Pore Particle Columns
Presented by: Adam Crowe, Ph.D. (Precision NanoSystems ULC), Lavelay Kizekai, B.S. (Waters Corporation), and Mandana Fasth, M.S. (Waters Corporation)
Presented Live: September 5, 2024
The recent pandemic has accelerated advancements in medicine, particularly with nucleic acid-based therapies such as mRNA, LNP delivery systems, and viral vectors. Ensuring the quality and integrity of these therapeutics is crucial, highlighting the importance of size exclusion chromatography (SEC) combined with MALS. This webinar will focus on using 1000 Å ultrawide pore columns with MALS to analyze long-chain nucleic acids, LNPs, and viral vector formulations, covering methods for mRNA integrity, LNP heterogeneity, and aggregate analysis.