Multi-Angle: October 2024
Low-Density Polyethylene - New insights into an old material under comparative studies
The molecular structure of low-density polyethylene (LDPE) strongly influences its applications. This study by Fraunhofer LBF and Chevron Phillips Chemical compared SEC-MALS, AF4-MALS, HT-HPLC, and 2D-LC. SEC-MALS offered key insights into branching and molecular weight, including how they impact function and depend on reactor technology.
Featured Customer: Henry Nguyen, Ph.D. – Asher Biotherapeutics
"SEC-MALS with the miniDAWN has been critical for determination of the molecular weight and polydispersity of our final material.”
Henry earned his Ph.D. in Molecular Biophysics and Biochemistry from Yale and works at Asher Biotherapeutics in protein engineering. His focus is on the developability assessment of bifunctional, glycosylated fusion proteins, with expertise in molecular biology and protein chemistry.
Overview of polymer analysis with light scattering technology
Wyatt Technology’s light scattering instruments and software provide absolute analysis of polymer molecular weight, size, conformation and branching. Whether you're optimizing for biodegradation or designing advanced polymer architectures, Wyatt’s solutions provide comprehensive polymer analysis supporting structure-function understanding.
New! - White Paper
Determination of multiple quality attributes of antibody-oligonucleotide conjugate with SEC-MALS and AEX-MALS
The study quantifies the oligonucleotide-to-antibody ratio (OAR) and identifies molecular species, including aggregates and fragments, in two AOC samples. This approach demonstrates how LC-MALS delivers robust, reproducible measurements of key quality attributes like payload heterogeneity, supporting the development of immunotherapeutic formulations.
Upcoming Events
Interactive roundtable on October 9th
Light scattering symposium and roundtable on polymer development and analysis
This interactive event features an expert panel of leading polymer scientists from the University of Pardubice, University of Chicago, University of Minnesota, University of Washington, Dow Chemical Company, and US Pharmacopeia. A range of topics will be discussed from novel polymer design to regulatory considerations.
Live webinar on October 15th
Using light scattering techniques for improved biotherapeutic characterization and development
Curious about light scattering and how it determines the critical quality attributes of biotherapeutics? Ready to learn about DLS, SLS, SEC-MALS, and RT-MALS? Join Prof. Histro Svilenov from the University of Ghent for a comprehensive overview of how light scattering aids biotherapeutic development.
Live webinar on October 23rd
Colloidal fingerprints of food and beverages with multidetector AF4-MALS
Food analysis is essential for consumer safety, but traditional methods can be complex and toxic. This webinar, led by Prof. Valentina Marassi and Prof. Andrea Zattoni from the University of Bologna and byFlow srl, will demonstrate how to merge sustainability with data maximization using AF4-DAD-MALS-dRI-FLD platforms for analyzing red wine and milk.